Wang J, Ciaraldi TP, Samad F. Tissue factor expression in obese type 2 diabetic subjects and its regulation by antidiabetic agents. J Obes. 2015;2015:291209.PDF
According to the World Health Organization, in 2014, more than 1.9 billion adults 18 years and older, were overweight. Of these over 600 million were obese. Insulin resistance, Type 2 Diabetes, and atherosclerosis are common complications of obesity. However, treatment options remain limited, in part due to the challenge of identifying suitable drug targets among the complex series of signaling pathways and cellular mediators that control the metabolic syndrome.