Investigators

James Binley, Ph.D.

Professor - HIV Vaccine Research

Dr. Binley earned his Ph.D. in Immunology/HIV in 1995 from The Scripps Research Institute and the University of Sheffield (UK). He completed a post-doctoral fellowship at Aaron Diamond AIDS Research Center in New York and was an Instructor at the Weill Medical College of Cornell University before returning to The Scripps Research Institute as Staff Scientist in 2001. In 2004, he established his laboratory at Torrey Pines Institute for Molecular Studies. In 2014 he joined SDBRI where he is Professor. Dr. Binley serves on grant review committees for the National Institute of Allergy and Infectious Diseases, and is reviewer for several scientific journals.

Select Publications

Crooks ET, Grimley SL, Cully M, Osawa K, Dekkers G, Saunders K, Rӓmisch S, Menis S, Schief WR, Doria-Rose N, Haynes B, Murrell B, Cale EM, Pegu A, Mascola JR, Vidarsson G, Binley JB. Glycoengineering HIV-1 Env Creates ‘Supercharged’ and ‘Hybrid’ Glycans to Increase Neutralizing Antibody Potency, Breadth and Saturation. PLoS Pathog. 2018 In press.

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Crooks ET, Osawa K, Tong T, Grimley SL, Dai YD, Whalen RG, Kulp DW, Menis S, Schief WR, Binley JM. Effects of partially dismantling the CD4 binding site glycan fence of HIV-1 Envelope glycoprotein trimers on neutralizing antibody induction. Virology. 2017 505:193-209.

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Cale EM, Gorman J, Radakovich NA, Crooks ET, Osawa K, Tong T, Li J, Nagarajan R, Ozorowski G, Ambrozak DR, Asokan M, Bailer RT, Bennici AK, Chen X, Doria-Rose NA, Druz A, Feng Y, Joyce MG, Louder MK, O’Dell S, Oliver C, Pancera M, Connors M, Hope TJ, Kepler TB, Wyatt RT, Ward AB, Georgiev IS, Kwong PD, Mascola JR, Binley JM. Virus-like Particles Identify an HIV V1V2 Apex-Binding Neutralizing Antibody that Lacks a Protruding Loop. Immunity. 2017 46:777-791.

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Crooks ET, Tong T, Chakrabarti B, Narayan K, Georgiev IS, Menis S, Huang X, Kulp D, Osawa K, Muranaka J, Stewart-Jones G, Destefano J, O’Dell S, LaBranche C, Robinson JE, Montefiori DC, McKee K, Du SX, Doria-Rose N, Kwong PD, Mascola JR, Zhu P, Schief WR, Wyatt RT, Whalen RG, Binley JM. Vaccine-Elicited Tier 2 HIV-1 Neutralizing Antibodies Bind to Quaternary Epitopes Involving Glycan-Deficient Patches Proximal to the CD4 Binding Site. PLoS Pathog. 2015 May 29;11(5):e1004932

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Cale EM, Doria-Rose NA, Tong T, Crooks ET, Nguyen R, Ambrozak DR, Perfetto SP, Roederer M, Binley JM, Mascola JR. Use of enzyme-digested virus-like particles as probes for flow cytometric sorting of HIV-specific neutralizing Ab-producing B-cells. AIDS Res Hum Retroviruses. 2014;30 Suppl 1:A20

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Tong T, Crooks ET, Osawa K, Robinson JE, Barnes M, Apetrei C, Binley JM. Multi-parameter exploration of HIV-1 virus-like particles as neutralizing antibody immunogens in guinea pigs, rabbits and macaques. Virology. 2014;456–457:55–69.

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All of Dr. James Binley’s Publications

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