Investigators

Maria Cecilia Marcondes, Ph.D.

Associate Professor
Neurological Disorders

Contact: cmarcondes@sdbri.org

Following a Major in Analytical Chemistry and a BSc in Behavioral Sciences, Dr. Cecilia Marcondes received an MS in Philosophy and a Ph.D. in Immunology from the Institute of Biomedical Sciences in the Universidade de Sao Paulo (USP), Brazil in 1996. She completed postdoctoral fellowships in the Department of Molecular Pathogenesis at the Skirball Institute, New York University Medical Center, and then in the Department of Neuropharmacology at The Scripps Research Institute, La Jolla, CA.

In 2011, she became Assistant Professor of Molecular and Integrative Neurosciences Department (MIND) at The Scripps Research Institute. Currently, she is also Adjunct Assistant Professor at the Scripps Research Neurosciences Department, and a member of several scientific societies, including the American Association of Immunology (AAI), and the Society for Neurosciences (SFN). She is currently an active member of the Diversity and Inclusion committee of the prestigious Society for Neuroimmune Pharmacology (SNIP).

Her recent studies have focused on central nervous system (CNS) dysfunctions associated with HIV infection and the roles played by co-morbidities such as drug abuse and aging, on aggravating neuroimmune pathogenesis. Her work on the role of neurotransmitters in modifying the immune response against the virus and promoting chronic inflammation uses a diversity of cell and animal models, and a multidisciplinary approach. She believes in the power of collaboration to advance science and promote rigor in the experimental design and execution process.

Select Publications

Basova LV, Kesby JP, Kaul M, Semenova S, Marcondes MCG. Systems Biology Analysis of the Antagonizing Effects of HIV-1 Tat Expression in the Brain over Transcriptional Changes Caused by Methamphetamine Sensitization. Viruses. 2020 Apr 9;12(4).

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Tjitro R, Campbell LA, Basova L, Johnson J, Najera JA, Lindsey A and Marcondes MC. Modeling the Function of TATA Box Binding Protein in Transcriptional Changes Induced by HIV-1 Tat in Innate Immune Cells and the Effect of Methamphetamine Exposure. Front Immunol. 2019;9:3110.

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Kesby JP, Chang A, Najera JA, Marcondes MCG, Semenova S. Brain Reward Function after Chronic and Binge Methamphetamine Regimens in Mice Expressing the HIV-1 TAT Protein. Curr HIV Res. 2019;17(2):126-133.

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Basova L, Najera JA, Bortell N, Wang D, Moya R, Lindsey A, Semenova S, Ellis RJ, Marcondes MCG. Dopamine and its receptors play a role in the modulation of CCR5 expression in innate immune cells following exposure to Methamphetamine: Implications to HIV infection. PLoS One. 2018;13(6):e0199861. doi: 10.1371/journal.pone.0199861. eCollection 2018. PubMed PMID: 29944719; PubMed Central PMCID: PMC6019408.

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Bortell N, Basova L, Najera JA, Morsey B, Fox HS, Marcondes MCG. Sirtuin 1-Chromatin-Binding Dynamics Points to a Common Mechanism Regulating Inflammatory Targets in SIV Infection and in the Aging Brain. J Neuroimmune Pharmacol. 2018;13(2):163-178.

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Kesby JP, Najera JA, Romoli B, Fang Y, Basova L, Birmingham A, Marcondes MCG, Dulcis D, Semenova S. HIV-1 TAT protein enhances sensitization to methamphetamineby affecting dopaminergic function. Brain Behav Immun. 2017. 65:210-221.

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Bortell N, Basova L, Semenova S, Fox HS, Ravasi T, Marcondes MCG. Astrocyte-specific overexpressed gene signatures in response to methamphetamine exposure in vitro. Journal of Neuroinflammation. 2017;14:49.

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Najera JA, Bustamante EA, Bortell N, Morsey B, Fox HS, Ravasi T, Marcondes MC. Methamphetamine abuse affects gene expression in brain-derived microglia of SIV-infected macaques to enhance inflammation and promote virus targets. BMC Immunol. 2016 Apr 23;17(1):7. doi: 10.1186/s12865-016-0145-0. PubMed PMID: 27107567; PubMed Central PMCID: PMC4841970.

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Bortell N, Morsey B, Basova L, Fox HS, Marcondes MCG. Phenotypic changes in the brain of SIV-infected macaques exposed to methamphetamine parallel macrophage activation patterns induced by the common gamma-chain cytokine system. Frontiers in Microbiology. 2015;6:900.

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All of Dr. Maria Cecilia Marcondes’ Publications

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