Investigators

Maria Cecilia Marcondes, Ph.D.

Professor - Neurological Disorders Research

Cecilia Marcondes received her Ph.D. in Immunology from the Universidade de Sao Paulo (USP), Brazil in 1996. She completed postdoctoral fellowships in the Department of Molecular Pathogenesis at the Skirball Institute, New York University, and then in the Department of Neuropharmacology of The Scripps Research Institute, La Jolla, CA. In 2011, she became Assistant Professor of the Molecular and Integrative Neurosciences Department (MIND) at The Scripps Research Institute. Currently, she is also an Adjunct Assistant Professor in the Molecular and Cellular Neurosciences Department (MCN) at The Scripps Research Institute. She is a member of the American Association of Immunology (AAI), Society for Neurosciences (SFN), and an active member of the Society for Neuroimmune Pharmacology (SNIP). Her recent studies have focused on central nervous system (CNS) dysfunctions associated with chronic HIV infection and the roles played by co-morbidities, such as drug abuse and aging, on aggravating neuro-immune pathogenesis.

Select Publications

Tjitro R, Campbell LA, Basova L, Johnson J, Najera JA, Lindsey A and Marcondes MC (2019) Modeling the Function of TATA Box Binding Protein in Transcriptional Changes Induced by HIV-1 Tat in Innate Immune Cells and the Effect of Methamphetamine Exposure. Front. Immunol. 9:3110. doi: 10.3389/fimmu.2018.03110

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Dopamine and its receptors play a role in the modulation of CCR5 expression in innate immune cells following exposure to Methamphetamine: Implications to HIV infection

Basova L, Najera JA, Bortel N, Wang D, Moya R, Alexander L, Semenova S, Ellis RJ, Marcondes M.

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Bortell N, Basova L, Najera JA, Morsey B, Fox HS, Marcondes MCG. Sirtuin 1-Chromatin-Binding Dynamics Points to a Common Mechanism Regulating Inflammatory Targets in HIV Infection and in the Aging Brain. J Neuroimmune Pharmacol. 2018 doi: 10.1007/s11481-017-9772-3. [Epub ahead of print]

Kesby JP, Najera JA, Romoli B, Fang Y, Basova L, Birmingham A, Marcondes MCG, Dulcis D, Semenova S. HIV-1 TAT protein enhances sensitization to methamphetamineby affecting dopaminergic function. Brain Behav Immun. 2017. 65:210-221.

Bortell N, Basova L, Semenova S, Fox HS, Ravasi T, Marcondes MCG. Astrocyte-specific overexpressed gene signatures in response to methamphetamine exposure in vitro. Journal of Neuroinflammation. 2017;14:49. doi:10.1186/s12974-017-0825-6.

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Najera JA, Bustamante EA, Bortell N, et al. Methamphetamine abuse affects gene expression in brain-derived microglia of SIV-infected macaques to enhance inflammation and promote virus targets. BMC Immunology. 2016;17:7. doi:10.1186/s12865-016-0145-0.

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Bortell N, Morsey B, Basova L, Fox HS, Marcondes MCG. Phenotypic changes in the brain of SIV-infected macaques exposed to methamphetamine parallel macrophage activation patterns induced by the common gamma-chain cytokine system. Frontiers in Microbiology. 2015;6:900.

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All of Dr. Maria Cecilia Marcondes’ Publications

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