Investigators

Fahumiya Samad, Ph.D.

Professor
Obesity, Adiopose Dysfunction & Cardiometabolic Disease

Research Focus

Dr. Samad’s research focuses on the contribution of adipose tissue to the pathogenesis of obesity and related health consequences including: insulin resistance, type 2 diabetes, fatty liver, increased risk for cardiovascular disease and cancer. She was a pioneer in demonstrating an endocrine role for adipose tissue by demonstrating that a number of pro-thrombotic and inflammatory proteins are expressed in adipocytes/adipose tissues and elevated in obesity. She has worked and published extensively on thrombotic (plasminogen activator inhibito-1, tissue factor) and inflammatory mediators, and related signaling pathways dysregulated in the obese adipose tissue and its consequences to the pathogenesis of the metabolic syndrome. Her research has been funded by grants from the NIH, American Heart Association, DOD, and the California Breast Cancer Research Program. Dr. Samad is Editor-in-Chief of Adipocyte, the first international peer-reviewed journal focusing exclusively on all aspects of adipose tissue physiology and pathology.


Education

Ph.D. in Biology, University of Wisconsin, 1990
M.S. in Zoology, University of Maine, 1984
B.Sc. (Honors) in Biology, University of Colombo, 1980


Professional Experience

2014 – Present, Current Professor, San Diego BioMed
2006 – 2014 Associate Member, Torrey Pines Institute for Molecular Studies
2004 – 2006 Associate Professor, La Jolla Institute for Molecular Medicine
1999 – 2004 Assistant Professor, The Scripps Research Institute
1996 – 1999 Senior Research Associate, The Scripps Research Institute
1992 – 1996 Post-Doctoral Fellow, The Scripps Research Institute
1989 – 1992 Associate Lecturer, Department of Biological Sciences, University of Milwaukee
1982 – 1984 Research Assistant, Cooperative Fisheries Research Unit, University of Maine
1980 – 1982 Assistant Lecturer/Research Assistant, Department of Biology, University of Colombo


Honors and Awards

American Heart Association, California Affiliate, Postdoctoral Fellowship Award, 1994
Fulbright Fellow, USIA and the Institute of International Education, 1982


Professional Activities

Editor-in Chief, Adipocyte
Editorial Board Member, ISRN Endocrinology
Editorial Board Member, Conference Papers in Cell Biology
Grant Reviewer, American Heart Association
Grant Reviewer, NIH
Member, American Diabetes Assocation
Member, American Association for the Advancement of Science
Member, American Heart Association, Council on Arteriosclerosis, Thrombosis and Vascular Biology
Member, International Society for Thrombosis and Homeostasis

Select Publications

Wang J, Ciaraldi TP, Samad F. Tissue factor expression in obese type 2 diabetic subjects and its regulation by antidiabetic agents. J Obes. 2015;2015:291209.

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Wang J, Badeanlou L, Bielawski J, Ciaraldi TP, Samad F. Sphingosine kinase 1 regulates adipose proinflammatory responses and insulin resistance. Am J Physiol Endocrinol Metab. 2014;306(7):E756-E768.

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Badeanlou L, Furlan-Freguia C, Yang G, Ruf W, Samad F. Tissue factor-protease activated receptor 2 signaling promotes diet-induced obesity and adipose inflammation. Nat Med. 2011;17(11): 1490–7.

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Neels GN, Badeanlou L, Hester KD, and Samad F. Keratinocyte-derived Chemokine in Obesity: Expression and Role in Adipose Macrophage Infiltration and Glucose homeostasis. J Biol Chem 2009;284(31):20692–8.

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Samad F, Uysal KT, Weisbrock SM, Pandey M, Hotamisligil GS, Loskutoff DJ. Tumor necrosis factor-a: A key component in the obesity-linked elevation of plasminogen activator inhibitor-1. Proc Natl Acad Sci USA. 1999;96(12): 6902–07

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Samad F, Yamamoto K, Loskutoff DJ. Distribution and regulation of plasminogen activator inhibitor-1 in murine adipose tissue in vivo: Induction by tumor necrosis factor-a and lipopolysaccharide. J Clin Invest. 1996; 97(1): 37–46.

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All of Dr. Fahumiya Samad’s Publications

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Our research programs are funded primarily by grants from the National Institutes of Health (NIH). Private donations help to accelerate the progress of research through the purchase of laboratory supplies and equipment or the recruitment of additional laboratory personnel. Thank you!

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