Investigators

Dave Gilbert, Ph.D.

Professor
Genome Structure & Function

Contact: gilbert@sdbri.org

Dave Gilbert focuses on the mechanisms regulating DNA replication during the cell cycle and the relationship between DNA replication and structural and functional organization of chromosomes, most recently during differentiation in human and mouse embryonic stem cells and in pediatric leukemia.

Dr. Gilbert received his BA degrees in Biochemistry/Cell Biology and Philosophy from the University of California at San Diego and his PhD in Genetics from Stanford University. He did two post-doctoral training periods, first as an EMBO Fellow with Pierre Chambon in Strasbourg, France studying transcriptional control, and second as a Roche Fellow with Melvin DePamphilis studying replication origin recognition. He joined the faculty at State University of New York (SUNY) Upstate Medical University in 1994 and was appointed Full Professor in 2003. In 2006, he moved to Florida State University where he served as J. Herbert Taylor Distinguished Professor of Molecular Biology in the Department of Biological Science and Co-founder and Associate Director of the Center for Genomics and Personalized Medicine at Florida State University (2006-2020).

He was elected as a Fellow of the American Association for the Advancement of Science (AAAS) in 2008 and then elected as a Council Delegate of the AAAS in 2010, as well as to the American Society of Hematology in 2013 and the International Society for Stem Cell Research in 2014.

Dr. Gilbert’s other awards include the American Cancer Society Junior Faculty Research Award (2000), the SUNY President’s Young Investigator Award (2002), the NIH Career Enhancement Award for Stem Cell Research (2004), Florida State University Distinguished Research Professor Award (2015), Florida State University Graduate Faculty Mentor award (2016) and the Pfeiffer Endowed Professorship for Cancer Research (2015). He is a former Principle Investigator in the NIH Encyclopedia of DNA Elements (ENCODE) Consortium (2011-2017), is a member of the NIH 4D Nucleome consortium and the Southeast Stem Cell Consortium (SESCC). He has served on American Cancer Society (1996–2004) and NIH study sections (1997–present), is an editorial member of the Epigenetics Society and is on the editorial board of the Journal of Cell Biology (2008 – present) and has authored over 160 publications.

Select Publications

Weitao Wang, Kyle Klein, Karel Proesmans, Hongbo Yang, Claire Marchal, Xiaopeng Zhu, Tyler Borman, Alex Hastie, Zhiping Weng, John Bechhoefer, Chun-Long Chen, David M. Gilbert, Nicholas Rhind. Genome-Wide Identification of Early-Firing Human Replication Origins by Optical Replication Mapping. MOLECULAR CELL, in press. bioRxiv 2020.08.24.263459; doi: https://doi.org/10.1101/2020.08.24.263459

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Kyle N. Klein, Peiyao A. Zhao, Xiaowen Lyu, Daniel A. Bartlett, Amar Singh, Ipek Tasan, Lotte P. Watts, Shin-ichiro Hiraga, Toyoaki Natsume, Xuemeng Zhou, Danny Leung, Masato T. Kanemaki, Anne D. Donaldson, Huimin Zhao, Stephen Dalton, Victor G. Corces, David M. Gilbert. Replication timing maintains the global epigenetic state in human cells SCIENCE, 2021 April 23;372(6540): 371-378. doi: 10.1126/science.aba5545. Epub 2021 Apr 22. PMID: 33888635.

Sarni, D., Sasaki, T., Miron, K., Tur-Sinai, M.I., Rivera-Mulia, J.C., Magnuson, B., Jjungman, M., Gilbert D.M. and Karem, B. (2020) 3D genome organization contributes to genome instability at fragile sites. NAT. COMM., 11(1):3613 (PMID: 32680994).

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Zhao, PA, Sasaki, T., Gilbert, D.M. (2020) High Resolution Repli-Seq defines the temporal choreography of initiation, elongation and termination of replication in mammalian cells. GENOME BIOL. 21: 76 (PMID: 32209126)

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Rivera-Mulia, JC, Sasaki, T., Trevilla-Garcia, C., Nakemichi, N., Knapp, DJHF, Hammond, C., Chang, B., Tyner, J.W., Devidas, M., Zimmerman, J., Klein, K.K., Somasundaram, V., Druker, B., Gruber, T., Koren, A., Eaves, C.J., Gilbert, D.M. (2019) Replication timing alterations in leukemia affect clinically relevant chromosome domains. BLOOD ADV. 3: 3201-3213 (PMID: 31698451)

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Marchal C., Sima J., Gilbert D.M. (2019) Control of DNA replication timing in the 4D genome. NATURE REV. MOL. CELL. BIOL., 20:721-737 (PMID: 31477886)

Dileep, V., Wilson, KA, Marchal, C, Lyu, X, Zhao, PA, Li, B., Poulet, A., Bartlett, D.A., Rivera-Mulia, JC, Qin, Z., Robins, A.J., Schulz, T.C., Kulik, M.J., Dalton S., Corces, V.G., Gilbert, D.M. (2019) Early differentiation of human embryonic stem cells is accompanied by rapid transcriptional re-programming and discordance between replication timing and chromatin compartment. STEM CELL REPORTS 13:193-206 (PMID: 31231024)

Sima J, Chakraborty A, Dileep V, Michalski M, Klein K.N., Holcomb N.P., Turner J.L., Paulsen M.T., Rivera-Mulia JC, Trevilla-Garcia C, Bartlett DA, Zhao PA, Washburn BK, Nora EP, Kraft K, Mundlos S, Bruneau BG, Ljungman M, Fraser P, Ay F, Gilbert DM. (2019) Identifying cis-Elements for Spatiotemporal Control of Mammalian DNA Replication. CELL 176:816-830 (PMID 30595451)

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All of Dr. Dave Gilbert’s Publications

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