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San Diego Biomedical Research Institute’s David Gilbert to be involved in new center for studying the structure of the cell

SDBRI’s David Gilbert will be joining a new multi-institution research center, directed by Carnegie Mellon University and funded by the National Institutes of Health. This center will develop a better understanding of the three-dimensional structure of cell nuclei and how changes in that structure affect cell functions in health and disease.

A growing body of research shows that the cell nucleus is highly compartmentalized and that this spatial phenomenon relates to cell function. But scientists don’t yet understand how compartmentalized structures in the nucleus tug and tether the chromosomes that carry the genetic code, as well as other biomolecules such as RNA and proteins.

The goal is to find causal relationships between the large-scale spatial genome structure and genome function, such as gene transcription and DNA replication. Once assembled, those multimodal data sets, including the multiscale navigation reference maps of nuclear organization—and the new computational tools and visualization platform created to make sense of them – will be made widely available to the research community.

The five-year, $10 million effort is being led by Principal Investigator Jian Ma and along with San Diego Biomedical Research Institute will include researchers at the University of California Los Angeles; the University of Illinois at Urbana-Champaign (UIUC); Harvard Medical School; Brown University; the Allen Institute for Cell Science; the University of Dundee; and the National Cancer Institute.

This work is supported by the NIH under award number 1UM1HG011593.

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