Promoting health and survival through lowered body temperature

San Diego BioMed would like to congratulate our own Conti Lab, on their most recent publication about temperature and aging biology! Paper publications in the San Diego BioMed sphere are always a testament to our labs’ hard work ethic, collaboration, and intellectual achievements.

In summary, this paper notes that calorie restriction (CR) is a balanced hypocaloric dietary regimen that slows aging and promotes longevity across species. Experimental work demonstrated that CR promotes health span by reducing the incidence and the progression of cancer as well as cardiovascular, metabolic, autoimmune and neurodegenerative diseases. The mechanisms by which hypocaloric diet exerts these beneficial effects are not fully understood and remain a fundamental subject of investigation for the development of therapeutic intervention. In this Perspective, Professor Bruno Conti and Rafa de Cabo summarize evidence indicating that the beneficial effects of CR are not entirely nor necessarily mediated by diet itself but by the lowering of body temperature occurring during CR. They also discuss how shifting the paradigm from diet to temperature opens new avenues for the study of aging biology and indicate what they believe are important avenues for future research with translational applications including temperature management and the development of temperature mimetics.

Read and learn more @ https://rdcu.be/eg1xL