Defective endomembrane dynamics in Rab27a deficiency impairs nucleic acid sensing and cytokine secretion in immune cells

San Diego BioMed is on a roll, as we excitingly congratulate another published paper from our team – the Baccala Lab. Join us in many congratulations to our own Roberto Baccala and Rosana Gonzalez, in collaboration with the Catz laboratory at Scripps.

In short summary, Dr. Baccala describes the detection of nucleic acids by endosomal Toll-like receptors (TLRs) as not only a critical event in the initiation of innate immune responses to infections, but also in the induction of lupus and other autoimmune diseases. This study identified Rab27a, a small GTPase, as a novel regulator of endosomal TLR responses. It was found that Rab27a deficiency impairs the internalization of nucleic acids, the intracellular trafficking of TLRs, TLR signaling, and the production and secretion of effector cytokines including type I interferon and IL-10 in neutrophils and plasmacytoid dendritic cells.

Read the article @ https://www.cell.com/cell-reports/fulltext/S2211-1247(24)00937-9?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS2211124724009379%3Fshowall%3Dtrue