CD16a pairs form the basal molecular subunit for the NK-cell ADCC lytic synapse

We extend our sincerest congratulations to the Murin Lab for the publication of their first official paper!

Read and learn more @ https://academic.oup.com/jimmunol/advance-article/doi/10.1093/jimmun/vkaf077/8164288#google_vignette

In this study, our researchers, Dr. Daniel Murin and Tania Cid, collaborated with labs at Scripps Research, Columbia University, and Abberior America to investigate the molecular landscape of the NK ADCC lytic synapse. Their trials show for the first time the oligomeric arrangement of the activating receptor CD16a on the surface of NK cells. Cutting-edge technology and techniques derived from the MINFLUX nanoscopy helped them localize CD16a with 2.5 nanometer spatial localization accuracy. The pairs of CD16a they found are likely the resting state of this receptor, and this could have implications for explaining disparities in antibody based therapeutic efficacy.

Dr. Murin comments, “we are so excited to make our mark in academia and are looking forward to building on this work in the future!”